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Semaglutide: How Much Weight Can You Lose in a Month?

Five essential facts about what you can realistically expect—and advice for success.
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If you’re considering using semaglutide for weight loss, you probably have lots of questions for your doctor. At the top of the list for many people: How much weight can I lose in a month? Or how quickly can I lose 20 pounds? (Another common question: Do I qualify? Take this short quiz to see find out.)

The answer to these questions is not as straightforward as you might think. “How much weight you’ll lose is truly individualized,” says Cathy Epps, PharmD, Chief Pharmacist at ReflexMD and an operational, clinical, and compliance consultant in Pompano Beach, Florida. “Every person’s body reacts differently to semaglutide.” 

Related: Your Top 5 Questions About Semaglutide, Answered

To understand why, it helps to understand how semaglutide works. Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist, according to the U.S. Food and Drug Administration. This means it imitates the function of a hormone called GLP-1, which gets released in your GI tract whenever you eat. 

GLP-1 prompts your body to increase its insulin production, which lowers your blood sugar. Semaglutide also signals your brain to control your appetite and creates a sensation of fullness in your stomach. But how quickly it prompts these changes—and the intensity of them—varies by person. 

The good news: Semaglutide is scientifically proven to help people lose weight, and it works for almost everyone. If you’re thinking about taking a semaglutide to assist your weight loss journey, talk to your doctor or chat with a ReflexMD Wellness Advisor now. Then, read on for five ways to improve your chances of success. 

Fact #1: Losing weight on semaglutide might not happen right away

A month is most likely not long enough to see major results on semaglutide. Taking it is not like being on a calorie-restrictive diet, where you can drop pounds right out of the gate. That happens because your body releases glycogen, a carbohydrate that makes you lose water weight, according to the Mayo Clinic.

Semaglutide doesn’t operate that way. Instead, you shed weight on it because it’s an appetite suppressant, the Cleveland Clinic explains. Depending on the person, this effect may not kick in all that quickly, although it will happen eventually. 

“You will experience appetite suppression, whether it starts in your first week or your tenth week,” says Dr. Epps. The smart move: Keep expectations in check.

Fact #2: You have to take semaglutide the right way—and shift your habits

A study from the University of Pennsylvania’s Perelman School of Medicine found that on average, patients lose 9.6% to 17.4% of their initial body weight at 15.5 months on the medication. 

To achieve results like this, you need to take semaglutide as recommended and with your doctor’s guidance. You’ll also have to follow a healthy reduced-calorie diet and exercise regularly, following your doctor’s advice on how often to work out. Semaglutide has magical qualities but it’s not a magic bullet.

Semaglutide-Is It Right for you? Find Out today!

Semaglutide, the same active ingredient as the weight loss drug Wegovy®—available today at 40% OFF.

Fact #3: You need to choose the right foods

You might not feel super-hungry once semaglutide starts to work in your body. This doesn’t mean you won’t be tempted by your favorite treats, though. 

“You could have a cupcake for dinner, but that wouldn’t be helpful,” Dr. Epps stresses. “Eating sugar, or something like white bread, will cause a spike in your blood sugar.” This can counteract the effectiveness of semaglutide, and if you eat like that regularly you may stop losing weight. 

Instead, go for healthy options from each food group. “You should eat protein, preferably at every meal,” says Dr. Epps. “This is because semaglutide can cause muscle loss. Other good choices for a balanced diet while taking semaglutide include veggies, nuts, and complex carbs.” 

Keep your portions sensible, depending upon how many calories per day your doctor recommends you eat. Craving a snack? Go ahead and indulge—about read the right way to snack when taking semaglutide first!

Fact #4: You can easily manage the side effects

A study in JAMA Network Open—which confirmed other findings that semaglutide is clinically effective for weight loss—found that the most common side effects are, in order, nausea, vomiting, diarrhea, and fatigue. (Read more about how to manage semaglutide side effects.)

These issues could make it harder to eat the healthy foods that help semaglutide function properly in your body—and make it tough to exercise as well. 

The solution? “Small, frequent meals spaced throughout the day,” says Dr. Epps. Eating this way will help settle your stomach and give you energy, and aid in keeping your blood sugar level as well. 

It also helps to be aware that these side effects tend to fade away!

Fact #5: Consistency is king

Losing weight with semaglutide means pacing yourself. If you stay consistent and do what’s instructed, you most likely will see results. Give yourself time to adjust—and celebrate each win as it comes.

If you think a weight loss medication like semaglutide might be right for you, chat with a ReflexMD Wellness Advisor now or take our short quiz to see if you qualify.

Read Next: The Ultimate Guide To Semaglutide

Semaglutide (Subcutaneous Route). Mayo Clinic. April 1, 2024.

Medications Containing Semaglutide Marketed for Type 2 Diabetes or Weight Loss. U.S. Food and Drug Administration. January 10, 2024.

Weight Loss. Mayo Clinic. April 9, 2024. 

Appetite Suppressants. Cleveland Clinic. November 20, 2023. 

Chao A et al. Clinical Insight on Semaglutide for Chronic Weight Management in Adults: Patient Selection and Special Considerations. Drug, Design, Development and Therapy. December 2022.

My Plate. United States Department of Agriculture. 2020-2025 Guidelines.

Ghusn W et al. Weight Loss Outcomes Associated With Semaglutide Treatment for Patients with Overweight or Obesity. JAMA Network Open. September 2022.

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Semaglutide, the same active ingredient as the weight loss drug Wegovy®—available today at 40% OFF.

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ReflexMD New Years Offer

Start the New Year strong!

Limited Time Offer

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Enter your information below to receive this offer.
By providing your email, you agree to our Terms and ConditionsPrivacy Policy, and Telehealth Consent. You also consent to receive promotional emails from ReflexMD. This consent is not a condition of purchase. You may unsubscribe at any time by clicking the unsubscribe link in our emails.
By providing your mobile number and submitting this form, you agree to receive marketing text messages (e.g. promos, cart/browse reminders) from ReflexMD at the number provided. Your consent is not a requirement for any purchase. Standard Msg & data rates may apply. Msg frequency varies. You can opt out at any time by replying STOP or clicking the unsubscribe link (where available). To learn more visit our Privacy Policy & Terms.

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